What is the human herpesvirus associated with Kaposi Sarcoma?

Kaposi Sarcoma is a type of cancer that is closely associated with infection by Human Herpesvirus 8 (HHV-8). This virus, also known as KSHV (Kaposi Sarcoma-associated herpesvirus), plays a significant role in the development of this malignancy, particularly in immunocompromised individuals, such as those living with HIV/AIDS. HHV-8 can cause the proliferation of endothelial cells, leading to the characteristic vascular tumors seen in Kaposi Sarcoma.

In contrast, the other herpesviruses listed are involved in different diseases: HHV-1 primarily causes oral herpes, HHV-2 is associated with genital herpes, and HHV-5 (Cytomegalovirus) typically leads to issues in immunocompromised patients but is not directly linked to Kaposi Sarcoma. Understanding the specific associations of these viruses with various diseases is crucial in fields such as oncology and infectious disease management.